Dr John Allen
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Senior Research Fellow (Cancer Institute NSW), Senior Research Fellow (Central Clinical School, University of Sydney) & Head, Cancer Drug Resistance Group
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology
D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia
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Research interests | Publications
Research interests
Drug resistance mechanisms in chemotherapy: multidrug transporters, apoptosis pathways, the unfolded protein response. New anticancer drugs, anticancer drug pharmacokinetics and toxicity. Animal models of tumorigenesis and drug resistance. Melanoma, myeloma and other common recalcitrant cancers.
Publications
2008
Ho, L., Kench, J., Handelsman, D., Scheffer, G., Stricker, P., Grygiel, J., Sutherland, R., Henshall, S., Allen, J., Horvath, L. Androgen regulation of multidrug resistance-associated protein 4 (MRP4/ABCC4) in prostate cancer. The Prostate. 2008; 68:1421-9. [Abstract]
Holland, M., Allen, J., Arnold, J. Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). European journal of pharmacology. 2008; 591:128-31. [Abstract]
Jiang, C., Lucas, K., Avery-Kiejda, K., Wade, M., deBock, C., Thorne, R., Allen, J., Hersey, P., Zhang, X. Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. Cancer Research. 2008; 68:6708-6717. [Abstract]
2007
Mhaidat, N., Zhang, X., Allen, J., Avery-Kiejda, K., Scott, R., Hersey, P. Temozolomide induces senescence but not apoptosis in human melanoma cells. British journal of cancer. 2007; 97:1225-33. [Abstract]
Holland, M., Lau, D., Allen, J., Arnold, J. The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. British journal of pharmacology. 2007; 152:815-24. [Abstract]
2006
Holland, M., Panetta, J., Hoskins, J., Bebawy, M., Roufogalis, B., Allen, J., Arnold, J. The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochemical pharmacology. 2006; 71:1146-54. [Abstract]
2005
Dilda, P., Don, A., Tanabe, K., Higgins, V., Allen, J., Dawes, I., Hogg, P. Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. Journal of the National Cancer Institute. 2005; 97:1539-47. [Abstract]
Allen, J., Zhang, X., Scott, C., Boyle, G., Hersey, P., Strasser, A. Is Apaf-1 expression frequently abrogated in melanoma?. Cell Death and Differentiation. 2005; 12:680-681. [Abstract]
Cabot, M., Yu, J., Kelly, G., Brown, D., Lucas, K., Tanabe, K., Allen, J. Phenoxodiol, a synthetic analog of genistein, generates ceramide and is equipotent in wild-type and multidrug-resistant human tumor cells. Journal of Clinical Oncology. 2005; 23:153S-153S. [Abstract]
Norris, M., Smith, J., Tanabe, K., Tobin, P., Flemming, C., Scheffer, G., Wielinga, P., Cohn, S., London, W., Marshall, G., Allen, J., Haber, M. Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro. Molecular cancer therapeutics. 2005; 4:547-53. [Abstract]
2004
Stam, R., van den Heuvel-Eibrink, M., den Boer, M., Ebus, M., Janka-Schaub, G., Allen, J., Pieters, R. Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2004; 18:78-83. [Abstract]
2003
Allen, J., Van Dort, S., Buitelaar, M., van Tellingen, O., Schinkel, A. Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein. Cancer research. 2003; 63:1339-1344. [Abstract]
van der Pol, M., Broxterman, H., Pater, J., Feller, N., van der Maas, M., Weijers, G., Scheffer, G., Allen, J., Scheper, R., van Loevezijn, A., Ossenkoppele, G., Schuurhuis, G. Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia. Haematologica. 2003; 88:134-147. [Abstract]
2002
Mikkers, H., Allen, J., Berns, A. Proviral activation of the tumor suppressor E2a contributes to T cell lymphomagenesis in EmuMyc transgenic mice. Oncogene. 2002; 21:6559-66. [Abstract]
Mikkers, H., Allen, J., Knipscheer, P., Romeijn, L., Hart, A., Vink, E., Berns, A., Romeyn, L. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nature genetics. 2002; 32:153-9. [Abstract]
Allen, J., Jackson, S., Schinkel, A. A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for Doxorubicin resistance. Cancer research. 2002; 62:2294-9. [Abstract]
Allen, J., van Loevezijn, A., Lakhai, J., van der Valk, M., van Tellingen, O., Reid, G., Schellens, J., Koomen, G., Schinkel, A. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Molecular cancer therapeutics. 2002; 1:417-25. [Abstract]
Allen, J., Schinkel, A. Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2). Molecular cancer therapeutics. 2002; 1:427-34. [Abstract]
2001
van Loevezijn, A., Allen, J., Schinkel, A., Koomen, G. Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines. Bioorganic & medicinal chemistry letters. 2001; 11:29-32. [Abstract]
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